Being on the Road ! in Hatena

タイトルは沢木耕太郎「深夜特急」トルコ編の「禅とは,途上にあること」という台詞から.

JECFAがCdの耐容摂取量を1カ月当たりの量として設定するように変更.

元記事はここ.いままでは1週間当たりの量(PTWI,Wはweek)として7 μg/kg body weightが設定されていたが,それを取りやめ,PTMI(Mはmonth)として25 μg/kg body weightを設定した.理由は,半減期が長いため.
本当はPTLI(Lはlifetime)とするのがカドミウムの場合は正しいと思うが,一生のうちには体重も変化するので...

The Committee noted that the existing health-based guidance value for cadmium was expressed on a weekly basis (provisional tolerable weekly intake, or PTWI), but, owing to cadmium’s exceptionally long half-life, considered that a monthly value was more appropriate. The Committee therefore withdrew the PTWI of 7 μg/kg body weight.
In view of the long half-life of cadmium, daily ingestion in food has a small or even a negligible effect on overall exposure. In order to assess long- or short-term risks to health due to cadmium exposure, dietary intake should be assessed over months, and tolerable intake should be assessed over a period of at least 1 month. To encourage this view, the Committee decided to express the tolerable intake as a monthly value in the form of a provisional tolerable monthly intake (PTMI). The Committee established a PTMI of 25 μg/kg body weight.
The estimates of exposure to cadmium through the diet for all age groups, including consumers with high exposure and subgroups with special dietary habits (e.g. vegetarians), examined by the Committee at this meeting are below the PTMI.